By studying the properties and behaviour of intramolecular and supramolecular systems in a systematic way, we seek to investigate the fundamental phenomena governing non-covalent interactions and chemical reactivity; i.e. the key determinants of structure and activity in chemical and biological systems.

We are developing nanopore-based biophysical approaches for monitoring the activity and conformational dynamics of molecular machines and enzymes in real-time. The method works on the principle that conformational changes in a single macromolecule held near (or threaded through) a transmembrane protein pore will induce tiny (but detectable) changes in the ion current flowing through the pore under an applied transmembrane potential (voltage).