Welcome to the PRIME download page. In order to save one of the files below, you will need to hold down the SHIFT key while you click on the file you want. This should then prompt you to save the file.

The PRIME II protocol is available here in portable document format (pdf). Following an MREC amendment dated 30 November 2008, this is currently the most up-to-date edition of the protocol. The scientific rationale document that supported the application may be found here (described as project summary for additional recruitment in the MREC approval letter).


The letter from MREC is here, in portable document format.
The patient information sheet is here, version 4.5, dated 30/11/2008.
The letter to the patient's GP is here, version 2.3, dated 30/11/2008.
And the consent form is here, version 1.3, dated 30/11/2008. This is not mentioned on the MREC approval letter, as approval was not required in order to make a change of date on a consent form. The confirmation of this from MREC Scotland can be found here

Instructions for completing the SSA online (for new centres or changes to PI)

The online form can be found at

  1. Create an account using your usual email address and a password (if you do not already have one). You will not need to give the password to anyone else.
  2. Once you have an account, email Linda Williams with the email address you used to create your account, and she will then make the online SSA available to you. The next time you log on, the PRIME form will be available to you.

If you have any problems with any of the files, then email Linda Williams. Technical queries should be addressed to the NRES Technical Help Desk.

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This page was written by Dr Linda Williams and last updated on 9th December 2008.