| We are interested
in developing instrumentation, and aim to be system rather than
technique led. A particular interest is to probe conformational
changes that occur as an indicator of biological activity, for example
[Ca]2+ binding to Calmodulin.
We are developing ion mobility as a tool to investigate
changes in protein and peptide conformation. This work is
supported by molecular mechanics based calculations which supply
candidate geometries to compare with those measured.
Some of our work is based on interrogating model systems,
as we seek a general understanding of biological processes. However,
strong collaborations with biological chemists and medical researchers,
enable us to also examine ‘real world’ problems.
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