We use a combination of experimental gas phase techniques, molecular modelling and solution chemistry methods to interrogate conformations of proteins, peptides and other natural products.

We are interested in developing instrumentation, and aim to be system rather than technique led. A particular interest is to probe conformational changes that occur as an indicator of biological activity, for example [Ca]2+ binding to Calmodulin.

We are developing ion mobility as a tool to investigate changes in protein and peptide conformation.  This work is supported by molecular mechanics based calculations which supply candidate geometries to compare with those measured.

Some of our work is based on interrogating model systems, as we seek a general understanding of biological processes. However, strong collaborations with biological chemists and medical researchers, enable us to also examine ‘real world’ problems.



 

 

 

 

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