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Dictyostelium discoideum developement

This was my first project as a PhD student with Paulien Hogeweg at Utrecht University in 1993. We constructed the first 3D model of uninterrupted Dictyostelium discoideum development from the aggregation to the crawling slug stages. We made use of the Cellular Potts Model that had just been developed by Francois Graner and Jim Glazer. We extended this model to include chemotaxis to cyclic-AMP which was modelled using partial differential equations. Without any changes in parameter values and with only differential adhesion and chemotaxis we showed that the amoebae could self-organise into streams, form a mound, sort into different cell types at the posterior and anterior positions and crawl as a slug. The mpeg movies below demonstrate this behaviour.

the streams
the slug
the cAMP

This work was published in the Journal of Theoretical Biology.

Document made with Nvu Created 11 April 2007.