4th Year Sex determination elective lecture material and relevant pdfs for you to download (University computers only)
lecture 1 Sex chromosomes and sex determination across vertebrates lecture 2 Sex chromosome dosage compensation lecture 3 Sex determination in Drosophila and other insects 1 lecture 4 Sex determination in Drosophila and other insects 2 lecture 5 Mammalian sex determination lecture 6 Mammalian sex determination 2
Sex determination elective seminar paper pdfs (2008-2009)
Tuesday 20 January 15.00-15.50 Dosage compensation in non-eutherian vertebrates Kuroiwa et al (2002)Biallelic expression of Z-linked genes in male chickens. Cytogenet Genome Res 99(1-4): 310-4. Itoh et al (2007)Dosage compensation is less effective in birds than in mammals. J Biol 6(1): 2. Deakin et al (2008)The status of dosage compensation in the multiple X chromosomes of the platypus." PLoS Genet 4(7): e1000140.
Tuesday 3 February 15.00-15.50 Sex determination in C.elegans
Hodgkin (2002)One Lucky XX Male: Isolation of the First Caenorhabditis elegans Sex Determination Mutants. Stothard, P., and Pilgrim (2004)Sex-determination gene and pathway evolution in nematodes. BioEssays 25.3, 221-229 Starostina et al. (2007)A CUL-2 ubiquitin ligase containing three FEM proteins degrades TRA-1 to regulate C.elegans sex determination. Dev. Cell. 2007 Jul:13(1): 127-39.
Tuesday 10 February 15.00-15.50 Mammalian sex Determination - the first steps
Chassot et al. (2008) Genetics of ovarian differentiation: Rspo1, a major player. Sex Dev, 2: 219-27. Sekido R & Lovell-Badge, R. (2008)Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer. Nature, 453: 930-4.
Thursday 08 Jan 2003 Temperature-sensitive sex determination in crocodiles. Robert & Thompson (2001)Sex determination: Viviparous lizard selects sex of embryos. Nature 412:698-699. Fleming & Crews (2001)Estradiol and Incubation Temperature Modulate Regulation of Steroidogenic Factor 1 in the Developing Gonad of the Red-Eared Slider Turtle. Endocrinology, v.142, No 4:1403-1411. Western, P.S., J.L.Harry, J.A.Marshall Graves, A.H.Sinclair(2000)Temperature-dependent sex determination in the American alligator: expression of SF1, WT1 and DAX1 during gonadogenesis. Gene, v.241: 223-232.
