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Lecture material and relevant pdfs for you to download (University computers only)

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4th Year Gene Expression Core Course

lecture 1 Chromosome organization and gene expression
lecture 2 Epigenetic gene expression
lecture 3 Sex chromosome epigenetics


Lecture 1 Handout
Lecture 2 Handout
Lecture 3 Handout

2009 Core lecture reference pdfs

Lecture 1: Chromosome organization and gene expression
Allshire RC, Karpen GH (2008). . Epigenetic regulation of centromeric chromatin: old dogs, new tricks? Nature Reviews Genetics, 9: 923.
Meaburn KJ, Misteli T (2007). Chromosome territories. Nature, 445: 379-381.

Lecture 2: Epigenetic Gene Expression

Baylin SB, Schuebel KE (2007). Genomic biology: the epigenomic era opens. Nature;448(7153):548-9.
Fuks 2005. DNA methylation and histone modifications: teaming up to silence genes. Curr Opin Genet Dev. 2005 Aug 9; 15: 1-6
Suzuki MM, Bird A 2008. DNA methylation landscapes: provocative insights from epigenomics. Nat Rev Genet.9(6):465-76.
Pauler FM and Barlow DP 2006. Imprinting mechanisms-it only takes two. Genes & Dev., 20: 1203-1206.

Lecture 3: Sex Chromosome Dosage Compensation
Thorvaldsen, Verona, Bartolomei (2006) X-tra! X-tra! News from the mouse X chromosome. Developmental biology 298(2):344-53.
Heard and Disteche. (2006) Dosage compensation in mammals: fine-tuning the expression of the X chromosome. Genes and Dev., 20: 1848-1867.
Angelopoulou R, Lavranos G, Manolakou P. (2008) Regulatory RNAs and chromatin modification in dosage compensation: a continuous path from flies to humans? Reprod Biol Endocrinol. 6:12.

Listen to the school of Biology podcast for March 2007 featuring Adrian Bird discussing Rett syndrome and phenotypic reversal in mice.

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