Group Publications

2012

36. DOI Enantioselective Copper-Catalyzed Reductive Coupling of Alkenylazaarenes with Ketones, Saxena, A.; Choi, B.; Lam, H. W. J. Am. Chem. Soc. 2012, 134, Just Accepted.

35. DOI Enantioselective Rhodium-Catalyzed Addition of Potassium Alkenyltrifluoroborates to Cyclic Imines, Luo, Y.; Carnell, A. J.; Lam, H. W. Angew. Chem., Int. Ed. 2012, 51, in press.

34. DOI Enantioselective Rh(I)-Catalyzed Cyclization of Arylboron Compounds onto Ketones, Low, D. W.; Pattison, G.; Wieczysty, M. D.; Churchill, G. H.; Lam, H. W. Org. Lett. 2012, 14, ASAP.

33. DOI Palladium-catalyzed hydroacyloxylation of ynamides, Smith, D. L.; Goundry, W. R.; Lam, H. W. Chem. Commun. 2012, 48,1505-1507.
Appearing in a special "Emerging Investigators" issue

2011

32. DOI Enantioselective rhodium-catalyzed arylation of electron-deficient alkenylarenes, Saxena, A.; Lam, H. W. Chem. Sci. 2011, 2, 2326-2331.

31. DOI TADDOL-Derived Phosphonites, Phosphites, and Phosphoramidites in Asymmetric Catalysis, Lam, H. W. Synthesis 2011, 2011-2043.
Review

30. DOI Ytterbium-Catalyzed Conjugate Allylation of Alkylidene Malonates, Fallan, C.; Quigley, P. F.; Lam, H. W. J. Org. Chem. 2011, 76, 4112-4118.

29. DOI Base-catalyzed synthesis of bicyclic 4-aminopyrimidines from the reaction of dinitriles with mononitriles, Chercheja, S.; Simpson, J. K.; Lam, H. W. Tetrahedron 2011, 67, 3839-3845.

2010

28. DOI Enantioselective Rhodium-Catalyzed Addition of Arylboronic Acids to Alkenylheteroarenes, Pattison, G.; Piraux, G.; Lam, H. W. J. Am. Chem. Soc. 2010, 132, 14373-14375.

27. DOI Catalytic Asymmetric Dihydroxylation of Enamides and Application to the Total Synthesis of (+)-Tanikolide, Gourdet, B.; Lam, H. W. Angew. Chem., Int. Ed. 2010, 49, 8733-8737.

26. DOI Rhodium-catalyzed carbometalation of ynamides with organoboron reagents, Gourdet, B.; Smith, D. L.; Lam, H. W. Tetrahedron 2010, 66, 6026-6031.
This work was featured on the front cover of issue 32 of Tetrahedron.

25. DOI Rhodium-Catalyzed Annulation of Ynamides with Bifunctional Arylboron Reagents, Gourdet, B.; Rudkin, M. E.; Lam, H. W. Org. Lett. 2010, 12, 2554-2557.

24. DOI Copper–Bisphosphine-Initiated Pentafluorophenylation of Aldehydes and Ketones, Brogan, S.; Carter, N. B.; Lam, H. W. Synlett 2010, 615-617.
Appearing in a special issue to celebrate Professor Gerald Pattenden's 70th birthday.

2009

23. DOI Enantioselective Copper-Catalyzed Reductive Michael Cyclizations, Oswald, C. L.; Peterson, J. A.; Lam, H. W. Org. Lett. 2009, 11, 4504-4507.

22. DOI Preparation of Multisubstituted Enamides via Rhodium-Catalyzed Carbozincation and Hydrozincation of Ynamides, Gourdet, B.; Rudkin, M. E.; Watts, C. A.; Lam, H. W. J. Org. Chem. 2009, 74, 7849-7858.

21. DOI Aromatic Heterocycles as Activating Groups for Asymmetric Conjugate Addition Reactions. Enantioselective Copper-Catalyzed Reduction of 2-Alkenylheteroarenes, Rupnicki, L.; Saxena, A.; Lam, H. W. J. Am. Chem. Soc. 2009, 131, 10386-10387.

20. DOI Stereoselective Synthesis of Multisubstituted Enamides via Rhodium-Catalyzed Carbozincation of Ynamides, Gourdet, B.; Lam, H. W. J. Am. Chem. Soc. 2009, 131, 3802-3803.

19. DOI Stereoselective Formation of Alkenyl Halides via Magnesium Halide Promoted Ring Opening of Bis-Activated Cyclopropenes, Wang, Y.; Lam, H. W. J. Org. Chem. 2009, 74, 1353-1355.

2008

18. DOI Synthesis and Application of Alkenylstannanes Derived from Base-Sensitive Cyclopropenes, Fordyce, E. A. F.; Luebbers, T.; Lam, H. W. Org. Lett. 2008, 10, 3993-3996.

17. DOI Stereoselective Synthesis of Tri- and Tetrasubstituted Alkenes by Iron-Catalyzed Carbometalation–Ring-Opening Reactions of Cyclopropenes, Wang, Y.; Fordyce, E. A. F.; Chen, F. Y.; Lam, H. W. Angew. Chem., Int. Ed. 2008, 47, 7350-7353.

16. DOI Formal synthesis of salinosporamide A using a nickel-catalyzed reductive aldol cyclization-lactonization as a key step, Villanueva Margalef, I.; Rupnicki, L.; Lam, H. W. Tetrahedron 2008, 64, 7896-7901.

15. DOI Racemic and asymmetric cobalt-catalysed reductive aldol couplings of α,β-unsaturated amides with ketones, Lumby, R. J. R.; Joensuu, P. M.; Lam, H. W. Tetrahedron 2008, 64, 7729-7740.

14. DOI Diastereoselective Cobalt-Catalyzed Alkylative Aldol Cyclizations Using Trialkylaluminum Reagents, Rudkin, M. E; Joensuu, P. M.; MacLachlan, W. S.; Lam, H. W. Org. Lett. 2008, 10, 2939-2942.

13. DOI Nickel-Catalyzed Reductive Aldol Cyclizations Using Diethylzinc as the Stoichiometric Reductant: Scope and Mechanistic Insight, Joensuu, P. M.; Murray, G. J.; Fordyce, E. A. F.; Luebbers, T.; Lam, H. W. J. Am. Chem. Soc. 2008, 130, 7328-7338.

12. DOI Copper-catalyzed silylation of cyclopropenes using (trifluoromethyl)trimethylsilane, Fordyce, E. A. F; Wang, Y.; Luebbers, T.; Lam, H. W. Chem. Commun. 2008, 1124-1126.

11. DOI Cobalt-catalyzed reductive Mannich reactions of 4-acryloylmorpholine with N-tosyl imines, Prieto, O.; Lam, H. W. Org. Biomol. Chem. 2008, 6, 55-57.

2007

10. DOI Diastereoselective Intermolecular Cobalt-Catalyzed Reductive Aldol Reactions of α,β-Unsaturated Amides with Ketones, Lumby, R. J. R.; Joensuu, P. M.; Lam, H. W. Org. Lett. 2007, 9, 4367-4370.

9. DOI Synthesis of Pyroglutamic Acid Derivatives via Double Michael Reactions of Alkynones, Scansetti, M.; Hu, X.; McDermott. B. P.; Lam, H. W. Org. Lett. 2007, 9, 2159-2162.

2006

8. DOI Diastereoselective Cobalt-Catalyzed Reductive Aldol Cyclizations Using Diethylzinc as the Stoichiometric Reductant, Lam, H. W.; Joensuu, P. M.; Murray, G. J.; Fordyce, E. A. F.; Prieto, O.; Luebbers, T. Org. Lett. 2006, 8, 3729-3732.

2005

7. DOI Diastereoselective Synthesis of 4-Hydroxypiperidin-2-ones via Cu(I)-Catalyzed Reductive Aldol Cyclization, Lam, H. W.; Murray, G. J.; Firth, J. D. Org. Lett. 2005, 7, 5743-5746.

6. DOI Cu(I)-Catalyzed Reductive Aldol Cyclizations: Diastereo- and Enantioselective Synthesis of β-Hydroxylactones, Lam, H. W.; Joensuu, P. M. Org. Lett. 2005, 7, 4225-4228.

Previous Publications

5. DOI A New Copper Acetate-Bis(oxazoline) Catalyzed, Enantioselective Henry Reaction, Evans, D. A.; Seidel, D.; Rueping, M.; Lam, H. W.; Shaw, J. T.; Downey, C. W. J. Am. Chem. Soc. 2003, 125, 12692-12693.

4. DOI Enantioselective Indole Friedel-Crafts Alkylations Catalyzed by Bis(Oxazolinyl)pyridine-Scandium(III) Triflate Complexes, Evans, D. A.; Scheidt, K. A.; Fandrick, K. R.; Lam, H. W.; Wu, J. J. Am. Chem. Soc. 2003, 125, 10780-10781.

3. DOI Total Synthesis of the Presumed Amphidinolide A, Lam, H. W.; Pattenden, G. Angew. Chem., Int. Ed. 2002, 41, 508-511.

2. DOI Radical cascade processes leading to fused- and spiro-bicyclic ring systems, Robertson, J.; Lam, H. W.; Abazi, S.; Roseblade, S.; Lush, R. K. Tetrahedron 2000, 56, 8959-8965.

1. DOI Structure and total synthesis of benzylthiocrellidone, a novel dimedone-based vinyl sulfide from the sponge Crella spinulata, Lam, H. W.; Cooke, P. A.; Pattenden, G.; Bandaranayake, W. M.; Wickramasinghe, W. A. J. Chem. Soc., Perkin Trans. 1 1999, 847-848.