Software resources


MCALIGN: alignment of noncoding DNA sequences based on explicit models of indel evolution.

MLGENOMEU: Estimation of mutation parameters from mutation accumulation experiments.

DFE-alpha: Inference of the distribution of fitness effects of new deleterious mutations and the fraction (α) and relative rate (ω_a) of adaptive substitutions based on folded nucleotide polymorphism site frequency spectra and between-species nucleotide divergence by the method of Keightley and Eyre-Walker (2007) [PDF] and Eyre-Walker and Keightley (2009) [PDF].

DFE-adaptive: Inference of the distribution of fitness effects of new mutations, including the fraction (p_a) and fitness effects (s_a) of adaptive mutations, based on unfolded nucleotide polymorphism site frequency spectra by the method of Schneider et al. (2011) [PDF].