Ben Nevis

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Postgraduate Training:

Cancer Medicinal Chemistry:
4 year programme funded by CRUK

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  • Chemistry
  • EaStCHEM
  • Edinburgh

    • Publications

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    2011

  • Rapid Synthesis and Zebrafish Evaluation of a Phenanthridine-based Small Molecule Library

    L. R. Donaldson, S. Wallace, D. Haigh, E. E. Patton, A. N. Hulme, Org. Biomol. Chem., 2011, 9, 2233-2239.

    2010

  • Evans-Tishchenko Coupling of Heteroaryl Aldehydes

    P. D. Dorgan, J. Durrani, M. J. Cases-Thomas, A. N. Hulme, J. Org. Chem., 2010, 75, 7475–7478.

  • Synthesis and Application of a New Cleavable Linker for "Click"-based Affinity Chromatography

    F. Landi, C. M. Johansson, D. J. Campopiano, A. N. Hulme, Org. Biomol. Chem., 2010, 8, 56-59.

    2009

  • A Ring Rearrangement Approach to the Synthesis of Benzo[b]quinolizine and Benzoindolizine Architectures

    L. R. Donaldson, D. Haigh, A. N. Hulme, Synlett, 2009, 1587-1590.

  • Negative Ion ESI–MS Analysis of Natural Yellow Dye Flavonoids—An Isotopic Labelling Study

    H. McNab, E. S. B. Ferreira, A. N. Hulme, A. Quye, Int. J. Mass Spec., 2009, 284, 57-65.

    2008

  • Anti and Syn Glycolate Aldol Reactions with a Readily Displaced Thiol Auxiliary

    S. Fanjul, A. N. Hulme, J. Org. Chem., 2008, 73, 9788-9791.

  • Enabling Methodology for the End Functionalisation of Glycosaminoglycan Oligosaccharides

    E. Gemma, O. Meyer, D. Uhrín, A. N. Hulme, Mol. BioSyst., 2008, 4, 481-495.

  • A Study of Heck Cyclization Reactions to Form Phenanthridine Ring Systems

    L. R. Donaldson, D. Haigh, A. N. Hulme, Tetrahedron, 2008, 64, 4468-4477.

  • Chemoenzymatic and Chemical Routes to the Nonproteinaceous Amino Acid Albizziine and its Amide Derivative

    N. A. Dobrovinskaya, I. Archer, A. N. Hulme, Synlett, 2008, 513-516.

  • Towards the Identification of Characteristic Minor Components from Textiles Dyed with Weld (Reseda luteola L.) and Those Dyed with Mexican Cochineal (Dactylopius coccus Costa)

    D. A. Peggie, A. N. Hulme, H. McNab, A. Quye, Microchim. Acta, 2008, 162, 371-380.

    2007

  • Biotinylated Anisomycin: A Comparison of Classical and "Click" Chemistry Approaches

    I. A. Inverarity, R. F. H. Viguier, P. Cohen, A. N. Hulme, Bioconj. Chem., 2007, 18, 1593-1603.

  • New Highly Selective and Easily Displaced Chiral Auxiliary for Boron Mediated Aldol Reactions

    A. N. Hulme, S. Fanjul, J. W. White, Abstr. Papers Am. Chem. Soc., 2007, 234, 992 (ORGN).

  • DMT-MM Mediated Functionalisation of the Non-Reducing End of Glycosaminoglycans

    E. Gemma, A. N. Hulme, A. Jahnke, L. Jin, M. Lyon, R. M. Müller, D. Uhrín, Chem. Commun., 2007, 2686-2688.

  • An Evans-Tishchenko – Ring Closing Metathesis Approach to Medium Ring Lactones

    J. I. Aird, A. N. Hulme, J. W. White, Org. Lett., 2007, 9, 631-634.

  • Marked Small Molecule Libraries: A Truncated Approach to Molecular Probe Design

    I. A. Inverarity, A. N. Hulme, Org. Biomol. Chem., 2007, 5, 636-643.

    2006

  • Achieving High Selectivity and Facile Displacement with a New Thiol Auxiliary for Boron Mediated Aldol Reactions

    S. Fanjul, A. N. Hulme, J. W. White, Org. Lett., 2006, 8, 4219-4222.

  • A Sensitised Europium Complex Generated by Micromolar Concentrations of Copper(I): Towards the Detection of Copper(I) in Biology

    R. F. H. Viguier, A. N. Hulme, J. Am. Chem. Soc., 2006, 128, 11370-11371.
    This paper was highlighted by Otto Wolfbeis in Angewandte Chemie.

  • Marked Small Molecule Libraries: A New Approach to Molecular Probe Design

    I. A. Inverarity, A. N. Hulme, P. Cohen, Abstr. Papers Am. Chem. Soc., 2006, 232, 902 (ORGN).

    2005

  • Negative Ion Electrospray Mass Spectrometry of Neoflavonoids

    A. N. Hulme, H. McNab, D. A. Peggie, A. Quye, Phytochemistry, 2005, 66, 2766-2770.

  • The Analytical Characterisation of the Main Component Found in Logwood Dyed Textile Samples after Hydrochloric Acid Extraction

    A. N. Hulme, H. McNab, D. A. Peggie, A. Quye, I. Vanden Berghe, J. Wouters, Preprints of the 14th Triennial Meeting of the ICOM Committee for Conservation, Vol.1I, J. Bridgland Ed., James & James, London, 2005, 783-788.

  • The Application of Liquid Chromatography-Mass Spectrometry and Accelerated Light Ageing for the Analytical Identification of Yellow Flavonoid Dyes in Historical Tapestries

    A. N. Hulme, H. McNab, D. A. Peggie, A. Quye, in Scientific Analysis of Ancient and Historic Textiles, P. Wyeth & R. Jananway (Eds), Archetype, London, 2005, 208-213.

  • Targeting Anisomycin Receptors: A Chemical Biology Approach to Protein Identification

    R. F. H. Viguier, I. A. Inverarity, P. Cohen, A. N. Hulme, Abstr. Papers Am. Chem. Soc., 2005, 230, 521 (ORGN).

  • An Efficient Synthesis of Substituted Hydrazides

    D. J. Benstead, A. N. Hulme, H. McNab, P. Wight, Synlett, 2005, 1571-1574.

    2004

  • The Natural Constituents of Historical Textile Dyes

    E. S. B. Ferreira, A. N. Hulme, H. McNab, A. Quye, Chem. Soc. Rev., 2004, 33, 329-336.

  • Synthetic Anisomycin Analogues Activating the JNK/SAP1 and p38/SAPK2 Pathways

    E. M. Rosser, S. Morton, K. S. Ashton, P. Cohen, A. N. Hulme, Org. Biomol. Chem., 2004, 2, 142-149.

    2003

  • Stereoselective Synthesis of the α-Glucosidase Inhibitor Nectrisine

    A. N. Hulme, C. H. Montgomery, Tetrahedron Lett., 2003, 44, 7649-7653.

  • LC-Ion Trap MS and PDA-HPLC – Complementary Techniques in the Analysis of Different Components of Flavonoid Dyes. The Example of Persian Berries (Rhamnus sp.)

    E. S. B. Ferreira, A. N. Hulme, H. McNab, A. Quye, Dyes in History and Archaeology, 2003, 19, 19-23.

  • LC-Ion Trap MS and PDA-HPLC – Complementary Techniques in the Analysis of Flavonoid Dyes in Historic Textiles. The Case Study of an 18th Century Herald’s Tabard

    E. S. B. Ferreira, A. Quye, A. N. Hulme, H. McNab, Dyes in History and Archaeology, 2003, 19, 13-18.

  • An Historical and Analytical Study of Red, Pink, Green and Yellow Colours in Quality 18th and Early 19th Century Scottish Tartans

    A. Quye, H. Cheape, J. Burnett, E. S. B. Ferreira, A. N. Hulme, H. McNab, Dyes in History and Archaeology, 2003, 19, 1-12.

  • Chiral Monomers with Minimal Functional Group Linkages for Suspension Co-polymerisation: A Suzuki Coupling Approach

    A. N. Hulme, S. A. Barron, A. J. Walker, Synlett, 2003, 1096-1100.

    2002

  • Photo-oxidation Products of Quercetin and Morin as Markers for the Characterisation of Natural Flavonoid Yellow Dyes in Ancient Textiles

    E. S. B. Ferreira, A. Quye, H. McNab, A. N. Hulme, Dyes in History and Archaeology, 2002, 18, 63-72.

  • Approaches to the Synthesis of (2R,3S)-2-Hydroxymethylpyrrolindin-3-ol (CYB-3) and its C(3) Epimer: A Cautionary Tale

    A. N. Hulme, K. S. Curley, J. Chem. Soc., Perkin Trans. 1, 2002, 1083-1091.

  • An Aldol Based Approach to the Synthesis of the Antibiotic Anisomycin

    A. N. Hulme, E. M. Rosser, Org. Lett., 2002, 4, 265-267.

    2001

  • ‘2’,4’,6’-Trihydroxy-1-methoxyacetophenone monohydrate at 150 K

    E. S. B. Ferreira, A. N. Hulme, H. McNab, S. Parsons, A. Quye, Acta Cryst., Sect. C, 2001, C57, 211-212.

  • Development of Analytical Techniques for the Study of Natural Yellow Dyes in Historical Textiles

    E. S. B. Ferreira, A. Quye, H. McNab, A. N. Hulme, J. Wouters, J. J. Boon, Dyes in History and Archaeology, 2001, 16/17, 179-186.

    2000

  • Stereoselective Reactions of Serine Derived Synthons: Applications to Natural Product Synthesis

    A. N. Hulme, K. S. Curley, C. H. Montgomery, Abstr. Papers Am. Chem. Soc., 2000, 220, 097 (ORGN).

  • A Flexible and Efficient Synthesis of the Pyrrolidine α-Glycosidase Inhibitor 1,4-Dideoxy-1,4-imino-arabinitol (DAB-1)

    A. N. Hulme, C. H. Montgomery, D. K. Henderson, J. Chem. Soc., Perkin Trans. 1, 2000, 1837-1841.

  • Polyether Total Synthesis

    A. N. Hulme, in The Chemical Synthesis of Natural Products, K. Hale Ed., Sheffield Academic Press, Sheffield, 2000, pp 63-95.

    1999

  • The Analytical Characterisation of Flavonoid Photodegradation Products: A Novel Approach to Identifying Natural Yellow Dyes in Ancient Textiles

    E. S. B. Ferreira, A. Quye, H. McNab, A. N. Hulme, J. Wouters, J. J. Boon, Preprints of the 12th Triennial Meeting of the ICOM Committee for Conservation, Vol.1, J. Bridgland Ed., James & James, London, 1999, 221-227.

    1998

  • Stereoselective Synthesis of the Immunomodulator Iminosugar Nectrisine and Related Analogues

    A. N. Hulme, C. H. Montgomery, K. S. Curley, Abstr. Papers Am. Chem. Soc., 1998, 216, 038 (ORGN).

  • Synthesis of β-Ketophosphonates from Thioester Intermediates: A Stereocontrolled Route to the C29-C35 Fragment of the Halichondramides

    A. N. Hulme, G. E. Howells, R. E. Walker, Synlett, 1998, 828-830.

    1997

  • Studies Towards the Synthesis of the Marine Metabolite, Octalactin A

    A. N. Hulme, G. E. Howells, Tetrahedron Lett. 1997, 38, 8245-8248.

  • Intramolecular Ring Cleavage of Chiral Terpenoid-Derived Oxazinone via Asymmetric Anti-Aldol Reaction: Unexpected Entry to a N-substituted Tetrahydro-1,3-oxazine-2,4-dione Derivative

    T. R. Abbas, J. I. G. Cadogan, A. A. Doyle, I. Gosney, P. K. G. Hodgson, G. E. Howells, A. N. Hulme, S. Parsons, I. H. Sadler, Tetrahedron Lett. 1997, 38, 4917-4920.

    1990-1995

  • Total Synthesis of (-)-Ebelactone-A and (-)-Ebelactone-B

    I. Paterson, A. N. Hulme, J. Org. Chem., 1995, 60, 3288-3300.

  • Asymmetric-Synthesis of the Key Intermediates Leading to (-)-Aphanorphine and (-)-Eptazocine

    A. N. Hulme, S. S. Henry, A. I. Meyers, J. Org. Chem., 1995, 60, 1265-1270.

  • Asmmetric-Synthesis of 1,1-Disubstituted Tetralins and Dihydronaphthalenes by Diastereoselective Addition of Lithiosilanes to Chiral Naphthalenes

    A. N. Hulme, A. I. Meyers, J. Org. Chem., 1994, 59, 952-953.

  • Stereocontrolled, 2-Directional, Chain Synthesis Using the Boron Aldol Recation and Double Ireland-Claisen Rearrangement

    I. Paterson, A. N. Hulme, D. J. Wallace, Tetrahedron. Lett., 1991, 32, 7601-7604.

  • Total Synthesis of the Esterase Inhibitor (+/-)-Ebelactone-A Using an Aldol-Claisen Strategy

    I. Paterson, A. N. Hulme, Tetrahedron Lett., 1990, 31, 7513-7516.